Dementia Research

What is LATE?

Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a recently characterized type of dementia. Similar to other forms of brain disorders, such as Alzheimer’s disease, LATE causes problems with memory and thinking but has different underlying causes. Researchers identified LATE based on results of autopsy studies that revealed abnormal clusters of a protein called TDP-43. TDP-43 is …

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Volunteers Needed for Studies to Advance Dementia Research

Interested in volunteering for research on Alzheimer’s disease, related dementias, and cognitive health? Learn about new and featured studies below or search for clinical trials and studies near you with the Alzheimers.gov Clinical Trials Finder. New and featured studies Click on the trial name for details and contact information. Caregiving Cognitive Training Daily Functioning Exercise and Supplements …

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Vision Impairment is Associated With as Many as 100,000 U.S. Dementia Cases

NIA-funded research suggests that existing treatments for vision problems — including eye exams, glasses prescriptions, and cataract surgery — could have potentially prevented about 100,000 cases of dementia in the United States. The study investigators used data from the University of Michigan Health and Retirement Study (HRS), a longitudinal study tracking changes in health and …

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Daily Multivitamin Use and Cognition in Older Adults

An NIA-funded research team at Wake Forest University School of Medicine aimed to fill the gaps in our understanding of multivitamins and flavanols — compounds found in high levels in unprocessed cocoa — and their effects on cognition. The study examined more than 2,200 participants, ages 65 and older, who enrolled in the study from …

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Nearly 40% of Older Adult Brains in an NIA-funded Study Showed Signs of LATE, a Form of Dementia

A recent NIA-funded study found that nearly 40% of participants had brain changes associated with limbic-predominant age-related TDP-43 encephalopathy (LATE). LATE is a recently characterized brain disorder that causes symptoms similar to Alzheimer’s disease but with different underlying causes. There is currently no way to diagnose LATE in living people. In this study, a team …

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